Sensory Cells and Circuits Lab

Publications

Selected Publications:

Chesler AT, Szczot M, Bharucha-Goebel D, et al. The role of PIEZO2 in human mechanosensation. The New England Journal of Medicine. 2016;375(14):1355-1364.
Lam RM, von Buchholtz LJ, Falgairolle M, Osborne J, Frangos E, Servin-Vences MR, Nagel M, Nguyen MQ, Jayabalan M, Saade D, Patapoutian A, Bönnemann CG, Ryba NJP, Chesler AT. PIEZO2 and perineal mechanosensation are essential for sexual function. Science. 2023;381(6660):906-910.
Servin-Vences MR, Lam RM, Koolen A, Wang Y, Saade DN, Loud M, Kacmaz H, Frausto S, Zhang Y, Beyder A, Marshall KL, Bönnemann CG, Chesler AT, Patapoutian A. PIEZO2 in somatosensory neurons controls gastrointestinal transit. Cell. 2023;186(16):3386-3399.e15.
Szczot M, Liljencrantz J, Ghitani N, Barik A, Lam R, Thompson JH, Bharucha-Goebel, Saade D, Necaise A, Donkervoort S, Foley AR, Gordon T, Case L, Bushnell MC, Bönnemann CG, Chesler AT. PIEZO2 mediates injury-induced tactile pain in mice and humans. Science Translational Medicine. 2018;10(462),eaat9892.
Barik A, Thompson JH, Seltzer M, Ghitani N, Chesler AT. A brainstem-spinal circuit controlling nocifensive behavior. Neuron. 2018;100(6):1491-1503.

Other Publications:

Case LK, Liljencrantz J, Madian N, Necaise A, Tubbs J, McCall M, Bradson ML, Szczot M, Pitcher MH, Ghitani N, Frangos E, Cole J, Bharucha-Goebel D, Saade D, Ogata T, Donkervoort S, Foley AR, Bönnemann CG, Olausson H, Bushnell MC, Chesler AT. Innocuous pressure sensation requires A-type afferents but not functional PIEZO2 channels in humans. Nature Communications. 2021;12(1):657.
von Buchholtz LJ, Ghitani N, Lam RM, Licholai JA, Chesler AT, et al. Decoding cellular mechanisms for mechanosensory discrimination. Neuron. 2021;109(2):285-298.
Romero LO, Caires R, Nickolls AR, Chesler AT, et al. A dietary fatty acid counteracts neuronal mechanical sensitization. Nature Communications. 2020;11(1):2997.
Marshall KL, Saade D, Ghitani N, Coombs AM, Szczot M, Keller J, Ogata T, Daou I, Stowers LT, Bönnemann CG, Chesler AT, et al. Nature. 2020;588(7837):290-295.
Nickolls AR, Lee MM, Espinoza DF, Szczot M, Lam R, Nguyen MQ, Ryba NJ, Ward ME, Zou J, Wang Q, Beers J, Solinski HJ, Hoon MA, AlJanahi AA, Johnson KR, Chesler AT, et al. Transcriptional programming of human mechanosensory neuron subtypes. Cell Reports. 2020;30(3):932-946.
Wlaschin JJ, Gluski JM, Nguyen E, Silberberg H, Thompson JH, Chesler AT, et al. Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury. eLife. 2018;7:e33910.
Barik A, Thompson JH, Seltzer M, Ghitani N, Chesler AT. A brainstem-spinal circuit controlling nocifensive behavior. Neuron. 2018;100(6):1491-1503.
Szczot M, Liljencrantz J, Ghitani N, Barik A, Lam R, Thompson JH, Bharucha-Goebel, Saade D, Necaise A, Donkervoort S, Foley AR, Gordon T, Case L, Bushnell MC, Bönnemann CG, Chesler AT. PIEZO2 mediates injury-induced tactile pain in mice and humans. Science Translational Medicine. 2018;10(462), eaat9892.
Szczot M, Pogorzala LA, Solinski HJ, Young L, Yee P, Le Pichon CE, Chesler AT, et al. Cell-type-specific splicing of Piezo2 regulates mechanotransduction. Cell Reports. 2017;21(10)2760-2771.
Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes MJ, Chesler AT. Specialized mechanosensory nociceptors mediating rapid responses to hair pull. Neuron. 2017;95(4):944-954.
Chesler AT, Szczot M, Bharucha-Goebel D, et al. The role of PIEZO2 in human mechanosensation. The New England Journal of Medicine. 2016;375(14):1355-1364.

Full list of publications for Alexander Chesler, Ph.D., on PubMed.