Because of a lapse in Government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding Government operating status and resumption of normal operations can be found at OPM.gov.

NCCIH Clinical Trials Funding Opportunities

The National Center for Complementary and Integrative Health (NCCIH) no longer accepts most clinical trial applications through the Parent R01 (NOT-AT-20-001). Instead, NCCIH has published a series of clinical trial-specific Notices of Funding Opportunities (NOFOs) for investigators to use instead of the Parent R01. These NOFOs focus on 1) mind and body intervention studies and 2) natural product studies, targeting support of all phases of clinical intervention development.

NCCIH Research Framework - Basic (How does it work?), Mechanistic and Translational (Can the mechanistic effect be measured reliably; could it translate to humans?), Intervention Refinement and Optimization (Can modification enhance impact or adherence?), Efficacy (Does it work when compared to appropriate comparison condition?), Effectiveness and Pragmatic Studies (Is it still effective when implemented in "real world" conditions?), Dissemination and Implementation Science (How do we facilitate uptake in various settings?)