Skip to main contentLink to External Link Policy

Because of a lapse in Government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding Government operating status and resumption of normal operations can be found at OPM.gov.

Examples of NCCIH-Funded Natural Products Clinical Trials

The research projects listed below are examples of studies supported by NCCIH for natural product clinical trials over the past 10 years.

K24

Patient-Oriented Research in Arginine Deficiency Syndromes
Emory University
Morris, Claudia R
1K24AT009893-01

P01

Chinese Herbal Medicine as a Novel Paradigm for Cancer Chemotherapy
Yale University
Cheng, Yung-chi
1P01CA154295-01A1

R01

REVIVE—Resveratrol To Enhance Vitality and Vigor in Elders
University of Florida
Anton, Stephen D
1R01AT007564-01A1

Clinical & Metabolic Effects of Altering N-3 & N-6 Fatty Acids in Migraine (RCT)
University of North Carolina at Chapel Hill
Mann, John Douglas
1R01AT007813-01A1

Efficacy of Open-Label Placebo, Double-Blind Placebo, and Peppermint Oil in IBS
Beth Israel Deaconess Medical Center
Lembo, Anthony J
1R01AT008573-01A1

Role of PUFA-Gene Interactions in Health Disparities
Wake Forest University Health Sciences
Chilton, Floyd H
1R01AT008621-01A1

Metals in the Trial To Assess Chelation Therapy 2 (TACT2M)
Mount Sinai Medical Center (Miami Beach)
Lamas, Gervasio A
1R01AT009273-01

Inositol Supplementation To Treat Reproductive and Metabolic Dysfunction in Polycystic Ovary Syndrome: A Double Blind RCT (INSUPP-PCOS)
Pennsylvania State University Hershey Medical Center
Legro, Richard S
1R01AT009484-01A1

Road to Discovery for Combination Probiotic BB-12 With LGG in Treating Autism Spectrum Disorder
University of Texas Health Science Center at Houston
Rhoads, Jon Marc
1R01HD095158-01

Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
University of Michigan at Ann Arbor
Harris, Richard E
1R01AT010381-01A1

Biological Signature and Safety of an Immunomodulatory Probiotic Intervention of Veterans With PTSD
University of Colorado Denver
Brenner, Lisa A
1R01AT010005-01A1

Analgesic and Subjective Effects of Terpenes Administered Alone and in Combination With THC: Potential THC- and Opioid-Sparing Effects of Myrcene and ß-Caryophyllene
University of California Los Angeles
Cooper, Ziva D
1R01AT010762-01

R21

Beneficial Effects of Quercetin in COPD—A Preliminary Clinical Trial
University of Michigan at Ann Arbor
Sajjan, Umadevi Sivanappa
1R21AT007357-01

Icariin To Prevent Corticosteroid-Related Memory Changes
University of Texas Southwestern Medical Center
Brown, E Sherwood
1R21AT007869-01

Phased Exploratory Clinical Studies of Harpagophytum procumbens’ Impact Upon the Biological Signature of Inflammatory Osteoarthritis
University of Missouri Kansas City
Gerkovich, Mary M
1R21AT009086-01

Role of Zinc in HIV Inflammation
Case Western Reserve University
McComsey, Grace A
1R21AT009153-01

R33

Optimization of Blood Levels of 25(OH)-Vitamin D in African Americans
Louisiana State Univ Health Science Center Shreveport
Jain, Sushil K
1R33AT010637-01A1

R34

Effect of Lactobacillus GG on Gut Permeability and Microbiome in VLBW Neonates
University of Maryland, Baltimore
Fasano, Alessio
1R34AT006945-01

Safety and Effect of L. reuteri on Biomarkers of Inflammation in Healthy Infants
University of Texas Health Science Center at Houston
Rhoads, Jon Marc
1R34AT006727-01A1

Curcuma longa L. in Rheumatoid Arthritis (CLaRA): Clinical Planning Study
University of Arizona
Funk, Janet L
1R34AT007837-01

R43

The First Pomegranate Seed Oil–Containing Medical Food for Gut and Immune Health
Biotherapeutics, Inc.
Hontecillas, Raquel
1R43AT010991-01

R61

Identifying Biological Signatures of N-Acetylcysteine for Non-Suicidal Self-Injury in Adolescents
University of Minnesota
Cullen, Kathryn Regan
1R61AT009995-01

Impact of Quercetin on Inflammatory and Oxidative Stress Markers in COPD
Temple University of the Commonwealth
Sajjan, Umadevi Sivanappa
1R61AT009991-01

Prebiotic Treatment in People With Schizophrenia
University of Maryland, Baltimore
Buchanan, Robert W
1R61AT009990-01

Development of Pregnenolone as a Treatment for Depression
University of Texas Southwestern Medical Center
Brown, E Sherwood
1R61AT009625-01A1

31P-MRS and Resting State Functional Connectivity Analysis of the Effects of 5-Hydroxytryptophan and Creatine for Antidepressant Augmentation in Patients With SSRI/SNRI-Resistant Major Depressive Disorder
University of Utah
Kious, Brent Michael
1R61AT010636-01A1

U01

Preparation for GTP Long-Term Clinical Study on Bone Health
Texas Tech University Health Sciences Center
Shen, Chwan-Li L
1U01AT006691-01A1

Creatine Safety and Efficacy in HD: Coordination and Statistical Center
University of Rochester
Schifitto, Giovanni
1U01AT008197-01

U19

Influence of Dietary Botanical Supplements on Biological and Behavioral Resilience
Icahn School of Medicine at Mount Sinai
Pasinetti, Giulio Maria
1U19AT010835-01

Spirulina Oral Supplement for Enhancing Host Resilience to Virus Infection
University of Mississippi
Khan, Ikhlas Ahmad
1U19AT010838-01

UG3

Omega-3 Fatty Acids for MDD With High Inflammation: A Personalized Approach
Emory University
Rapaport, Mark Hyman
1UG3AT008857-01

UH3

Trial To Assess Chelation Therapy 2- TACT2 CCC
Mount Sinai Medical Center (Miami Beach)
Lamas, Gervasio A
5UH3AT009149-03