Methodological Approaches for Whole Person Research Workshop

Agenda

September 29, 2021, 11:30 a.m.–5:30 p.m. ET

11:30–11:35 a.m. | Welcome

11:35 a.m.–12:20 p.m. | Opening Remarks and Setting the Stage

• Helene M. Langevin, M.D., Director, NCCIH

12:20–2:25 p.m. | Session One: How To Study Interconnected Systems: Observational Studies

Moderators:

• Janine Simmons, M.D., Ph.D., National Institute on Aging
• Qilu Yu, Ph.D., NCCIH

Speakers

• Cynthia Rudin, Ph.D., Duke University. A toolbox for isolating and studying parts of interconnected systems: almost matching exactly for observational causal inference
• Ziv Bar-Joseph, Ph.D., M.Sc., Carnegie Mellon University. Machine learning methods for studying dynamic, interconnected multisystems
• Daniel Bauer, Ph.D., University of North Carolina at Chapel Hill. A person-oriented approach to the analysis of interconnected, multicomponent systems: using latent class/profile analysis to identify prototypical profiles of risk
• Trey Ideker, Ph.D., University of California, San Diego. Towards a precision medicine based on interpretable machine learning
• Terrie Moffitt, Ph.D., Duke University. Measuring patients’ pace of biological aging with longitudinal data, growth curves, and elastic net regression of DNA methylation

Panel Discussion

2:25–2:40 p.m. 15-minute break

2:40–4:25 p.m. | Session Two: How To Study the Impact of Single Component Interventions or Manipulation on Multiple Interconnected Systems

Moderators:

• Bramaramba Kowtha, M.S., R.D.N., L.D.N., Office of Disease Prevention, National Institutes of Health (NIH) Office of the Director
• Elizabeth Barr, Ph.D., Office of Research on Women’s Health, NIH Office of the Director

Speakers

• Mimi Ghosh, Ph.D., George Washington University. Impact of sexual trauma on the interconnected outcomes of mental health and immune response
• Ramsey D. Badawi, Ph.D., University of California, Davis. Total-body positron emission tomography—a transformative tool for quantitative whole-person research
• Karyn Esser, Ph.D., University of Florida. Preclinical approaches for whole person research: lessons from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
• David Amar, Ph.D., Stanford University. Challenges and opportunities from the multiomic MoTrPAC project

Panel Discussion

4:25–5:25 p.m. | Roundtable Discussion I

Moderators:

• Wen Chen, Ph.D., M.M.Sc., NCCIH
• Judith Arroyo, Ph.D., National Institute on Minority Health and Health Disparities

Panelists:

• Marybel Robledo Gonzalez, Ph.D., University of California, San Diego
• Elaine Y. Hsiao, Ph.D., University of California, Los Angeles

5:25–5:30 p.m. | Closing Remarks

• Emmeline Edwards, Ph.D., NCCIH

5:30 p.m. | Adjourn

Agenda

September 30, 2021, 11:30 a.m.–5:30 p.m. ET

11:30–11:35 a.m. | Welcome

11:35 a.m.–1:50 p.m. | Session Three: How To Investigate the Impact of Multicomponent Interventions or Therapeutic Systems on a Single Outcome

Moderators:

• Ranjan Gupta, Ph.D., Fogarty International Center, NIH
• Miya Whitaker, Psy.D., M.A., Office of Research on Women’s Health, NIH

Speakers

• Lynne Shinto, N.D., M.P.H., Oregon Health & Science University. Methods for designing multicomponent interventions based on naturopathy
• Lynda Powell, Ph.D., M.Ed., Rush University. Addition of a mindfulness component to a conventional lifestyle intervention for sustained remission of the metabolic syndrome
• Linda Collins, Ph.D., New York University. Achieving intervention EASE (effectiveness, affordability, scalability, and efficiency) using the multiphase optimization strategy (MOST)
• Liliane Windsor, Ph.D., The University of Illinois at Urbana-Champaign. Community Wise: development of a multilevel intervention to reduce alcohol and substance misuse among formerly incarcerated men
• Mark P. Jensen, Ph.D., University of Washington. Identifying the mechanisms underlying multicomponent pain interventions
• Nadja Cech, Ph.D., University of North Carolina at Greensboro. Mass spectrometry metabolomics to identify bioactives and synergists in botanical medicines

Panel Discussion

1:50–2:00 p.m. 10-minute break

2:00–4:00 pm. | Session Four: How To Examine the Impact of Complex Multicomponent Interventions on Multisystem or Multiorgan Outcomes

Moderators:

• Yvonne Bryan, Ph.D., National Institute of Nursing Research
• Hye-Sook Kim, Ph.D., NCCIH

Speakers

• Rob Knight, Ph.D., University of California, San Diego. The microbiome and metabolome as a readout of complex interventions throughout the body
• Nicholas Schork, Ph.D., The Translational Genomics Research Institute. N-of-1 and aggregated N-of-1 studies for exploring multicomponent intervention effects on multiple health outcomes
• Inbal Nahum-Shani, Ph.D., University of Michigan. Multicomponent interventions: an organizing framework for selecting an experimental design
• Ross Hammond, Ph.D., The Brookings Institution. Using systems science for a multifaceted, multioutcome whole-of-community intervention to prevent childhood obesity
• Atul Butte, M.D., Ph.D., University of California, San Francisco. Precisely practicing medicine from 700 trillion points of data

Panel Discussion

4:00–5:00 p.m. | Roundtable Discussion II

Moderators:

• Wendy Weber, N.D., Ph.D., M.P.H., NCCIH
• Craig Hopp, Ph.D., NCCIH

Panelists:

• Scott Mist, Ph.D., M.Ac.O.M., Oregon Health & Science University
• Irene Headen, Ph.D., M.S., Drexel University

5:00–5:25 p.m. | Workshop Synthesis: Whole Person Research Methods

• Bruce Y. Lee, M.D., M.B.A., City University of New York

5:25-5:30 p.m. | Closing Remarks 

• Helene M. Langevin, M.D., Director, NCCIH

5:30 p.m. | Adjourn