An official website of the United States governmentBerberine and Weight Loss: What You Need To Know
What is berberine?
Berberine is a substance found in a variety of plants, including goldenseal, barberry, Oregon grape, and others. Plants containing berberine have a long history of use in both Ayurvedic and Chinese medicine. In modern times, plants containing berberine have been used for infections, skin diseases, digestive disorders, and other conditions. Berberine is currently being studied for its effects on diabetes and risk factors for heart disease. Recently, it has become popular as a potential weight loss aid.
Will taking berberine help me lose weight?
Some studies suggest that it might, but the evidence is not conclusive.
A 2022 review of 18 studies that examined the effect of berberine on body weight and 23 that examined its effect on body mass index (BMI; a value based on weight and height that may help determine whether a person has a healthy weight) found significant decreases in both weight and BMI in people who took berberine. Effects on weight were seen primarily in people who took berberine in doses of more than 1 gram per day and for more than 8 weeks. Many of the studies included in this review had a high risk of bias, and the outcomes of individual studies were inconsistent. Therefore, additional, high-quality research would be needed to allow definite conclusions to be reached about whether berberine reduces weight and BMI.
Assessing the effects of berberine is also difficult because the amounts and formulations of berberine used in different studies have varied widely, and most of the study participants had health problems, such as diabetes or fatty liver disease, that might have influenced the results. In addition, most studies that looked at the effects of berberine on weight and cardiovascular risk factors were conducted in Asian countries; very few were done in North America.
Is it safe to take berberine?
Some side effects of berberine have been reported in research studies, primarily gastrointestinal symptoms such as nausea, abdominal pain, bloating, constipation, or diarrhea.
Berberine may interact with medicines. For example, it has been shown to interact with cyclosporine, a drug used to prevent rejection of transplanted organs. If you take medicine, talk with your health care provider if you are considering taking berberine supplements.
Exposure to berberine has been linked to a harmful buildup of bilirubin in infants, which can cause brain damage. Therefore, berberine is likely to be unsafe for infants and may also be unsafe for use during pregnancy or while breastfeeding because of possible effects on the fetus or infant.
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Key References
- Asbaghi O, Ghanbari N, Shekari M, et al. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: a systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN. 2020;38:43-49.
- Chan E. Displacement of bilirubin from albumin by berberine. Biology of the Neonate. 1993;63(4):201-208.
- Li Z, Wang Y, Xu Q, et al. Berberine and health outcomes: an umbrella review. Phytotherapy Research. 2023;37(5):2051-2066.
- Neag MA, Mocan A, Echeverría J, et al. Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders. Frontiers in Pharmacology. 2018;9:557.
- Wu X, Li Q, Xin H, et al. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. European Journal of Clinical Pharmacology. 2005;61(8):567-572.
- Xin H-W, Wu X-C, Li Q, et al. The effects of berberine on the pharmacokinetics of ciclosporin A in healthy volunteers. Methods and Findings in Experimental and Clinical Pharmacology. 2006;28(1):25-29.
- Zamani M, Zarei M, Nikbaf-Shandiz M, et al. The effects of berberine supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis. Frontiers in Nutrition. 2022;9:1013055.
Other References
- Berberine. Alternative Medicine Review. 2000;5(2):175-177.
- Goldenseal. Drugs and Lactation Database. (LactMed). National Institute of Child Health and Human Development. Updated May 2021. Accessed at ncbi.nlm.nih.gov/books/NBK501866 on September 1, 2023.
- National Institute on Diabetes and Digestive and Kidney Diseases. Am I at a Healthy Weight? Accessed at niddk.nih.gov/health-information/weight-management/adult-overweight-obesity/am-i-healthy-weight on September 22, 2023.
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